What is the Life Expectancy of a Person With Glioblastoma?

Dr. Philip Henkin

September 1, 2022


You’re not alone if you have brain cancer and are worried about your life expectancy. Infiltrative cancers, like glioblastoma, have a concise survival rate. Unfortunately, it’s only about five percent. This number has remained stagnant for the past 50 years. However, the Glioblastoma Foundation is working to improve patient outcomes.

Median survival

The median survival of people with glioma has improved in recent years. A systematic review of 63 population-based studies with 22 primary analyses shows that survival after two years is now 18%, three-year survival is 11%, and five-year survival is 4%. This is a significant improvement, but the results do not indicate a definitive cause for the gain.

Several factors are associated with more prolonged survival in people with this disease. For example, people who were younger than 45 are more likely to survive, as do those with high Carnovsky performance scale scores. In addition, patients with IDH1 mutations or MGMT gene promoter methylation are likely to have more prolonged survival. However, the recurrence of GBM is almost universal, and the median survival for people with recurrent GBM is five to seven months.

Glioblastomas are most often found in the frontal lobes of the brain, although they can occur anywhere in the brain. They can also affect the spinal cord. A recent study of 573 patients found that combined therapy increased median survival from 12.1 months to 14.6 months. In addition, the two-year survival rate in the radiotherapy alone group was 8%, compared to 20% in the combination therapy group. These results are similar to earlier meta-analyses, and the within-population comparison should be less confounding.

Recurrence rate

The recurrence rate of glioblastomata’s tumors (GBM) is often high despite advances in treatment. Most patients have a poor prognosis, and recurrence is inevitable. However, there are ways to improve the chances of survival and reduce the risk of relapse. This report reviews the clinical and research literature on recurrence and considers novel therapeutic approaches. While recurrence is still an inevitable part of the course of this disease, there is much hope that it can be treated more effectively.

While the recurrence rate of glioblastomata’s tumors is high, the survival rate is also high. On average, patients with this type of cancer live between two to three years, although in some cases, they live longer than that. Unfortunately, the survival rate of glioblastoma was even lower 20 years ago.

In a new study, researchers evaluated a combination of hypo fractionated stereotactic radiotherapy and chemotherapy in patients with recurrent GBM. They found that the variety of these two treatments extended the survival of patients by an average of 12.5 months.

Treatment options

Glioblastoma is the most aggressive form of brain cancer and is most often diagnosed in older people. It spreads throughout the brain and can also apply outside the nervous system. However, most patients with glioblastoma will live less than a year after diagnosis. Despite the limited survival rates, there are a few treatment options available.

Some of these treatments involve immunotherapy. Immunotherapy may include dendritic cell vaccines, heat shock protein vaccines, and immune checkpoint inhibitors. These treatments may prove effective in some instances, but they are still in the experimental stage. Therefore, they may not be suitable for everyone with glioblastoma.

In some cases, treatment for glioblastoma may involve using chemotherapy. This medication is either taken orally or administered through an IV. Some of these drugs can also be given through a shunt that drains excess fluid from the brain. Patients receiving chemotherapy will likely experience cycles of treatment that last a few weeks. A break is often taken between cycles to evaluate the response of the tumor. In some cases, patients may also benefit from targeted therapy, which targets specific cell changes that fuel cancer growth.

Patients with glioblastoma

Glioblastoma is the most aggressive type of brain tumor. It can affect any age and can cause life-threatening symptoms. While most patients with this cancer die within three years, survivors are relatively rare and are rarely reported in the media. The average patient will survive 14 to 16 months after diagnosis, and the longest survivor may stay for up to 20 years.

Glioblastomas develop in brain cells called glial cells. These cells are critical for the function of the brain, but they can mutate and grow into cancerous tumors. The tumors are infiltrative and may spread to healthy brain tissue. This makes it necessary for patients to receive an interdisciplinary approach to their treatment. A high-quality surgical resection is an essential component of treatment for glioblastomas.

Glioblastoma patients typically have a survival rate of five to 10 years. This is a relatively low survival rate for a tumor of this type, but the Glioblastoma Foundation is committed to improving the outcomes of this cancer. Complex cancer has several treatments, including surgery, chemotherapy, and radiation. In addition to standard treatments, researchers are also testing new therapies to treat glioblastoma. Some of these include gene therapy to deliver anti-cancer genes to the tumor.